Mortality 40%
The experts predict new economical crisis
Millions of people are isolated
One virus carrier infects 1.4-2.5 of people

What about treatment?

Advanced laboratories around the world are working on a drug search. Already managed to decipher the genome of the virus and develop a vaccine, but it still has to pass a series of tests. Scientists tested the effects of existing antiviral agents on 2019-nCoV. There have been found 30 drugs of traditional and alternative medicine, which have a necessary antiviral effect. Among them, there are both, exotic agents that are rarely found and quite popular antiviral drugs.

So lopinavir and ritonavir are on this list. Both substances are used in the treatment of HIV and are the active ingredients of Kaletra.

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Generic Kaletra

Brand(s): Lopimune
Manufacturer: Cipla Limited
Dosage: 200mg + 50mg
Package:
€ 6.45 Per Pill
€ 387.03
Free AirMail shipping
€ 5.53 Per Pill
€ 663.51
Free AirMail shipping

Generic Kaletra contains a combination of lopinavir and ritonavir. Lopinavir and ritonavir are antiviral medications that prevent human immunodeficiency virus (HIV) cells from multiplying in your body.Lopinavir and ritonavir (Kaletra) is a combination medicine used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS.

Lopinavir and ritonavir tablet

What is this medicine?

LOPINAVIR and RITONAVIR are antiviral medications that prevent human immunodeficiency virus (HIV) cells from multiplying in your body.Lopinavir and ritonavir (Kaletra) is a combination medicine used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS.Kaletra may also be used for purposes not listed in this medication guide.

What should my health care professional know before I take this medicine?

Serious drug interactions can occur when certain medicines are used together with lopinavir and ritonavir. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using. Some medicines can cause unwanted or dangerous effects when used with Kaletra. Your doctor may need to change your treatment plan if you use any of the following drugs:
  • alfuzosin;
  • pimozide;
  • rifampin;
  • lovastatin, simvastatin;
  • midazolam, triazolam;
  • sildenafil (Revatio for pulmonary arterial hypertension);
  • St. John's wort; or
  • an ergot medicine (ergotamine, dihydroergotamine, methylergonovine).
To make sure Kaletra is safe for you, tell your doctor if you have:
  • liver disease (especially hepatitis B or C);
  • heart disease or a heart rhythm disorder;
  • a personal or family history of Long QT Syndrome;
  • pancreas problems;
  • diabetes;
  • low levels of potassium in your blood;
  • a bleeding disorder such as hemophilia;
  • high cholesterol or triglycerides; or
  • if you have ever used a protease inhibitor in the past.
It is not known whether this medicine will harm an unborn baby. But HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Kaletra on the baby. Kaletra can make birth control pills or patches less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Kaletra. Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. Kaletra is not approved for use by anyone younger than 14 days old. Premature infants should not receive the medication until it has been 14 days after their original due date.

How should I take this medicine?

Follow all directions on your prescription label, especially when giving the medicine to a child. Do not take this medicine in larger or smaller amounts or for longer than recommended. If a child is taking this medication, tell your doctor if the child has any changes in weight. Kaletra doses are based on weight in children. Do not crush, chew, or break a Kaletra tablet. Swallow the pill whole. Kaletra tablets can be taken with or without food. While using Kaletra, you may need frequent blood tests at your doctor's office. HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

What may interact with this medicine?

Many drugs can interact with Kaletra. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
  • antiviral medicines to treat hepatitis C or HIV;
  • cancer medicine;
  • medicine to prevent organ transplant rejection;
  • "statin" cholesterol-lowering medicine;
  • an antibiotic--bedaquiline, clarithromycin, metronidazole, rifabutin;
  • antifungal medicine--itraconazole, ketoconazole, voriconazole;
  • heart or blood pressure medicine--amiodarone, felodipine, lidocaine, nicardipine, nifedipine, quinidine;
  • medicine to prevent blood clots--rivaroxaban, warfarin (Coumadin, Jantoven);
  • medicine to treat impotence or pulmonary arterial hypertension--avanafil (Stendra), sildenafil (Viagra, Revatio), tadalafil (Adcirca, Cialis), or vardenafil (Levitra, Staxyn);
  • medicine to treat severe depression or schizophrenia--bupropion (Wellbutrin, Zyban), quetiapine, trazodone;
  • narcotic medicine--fentanyl, methadone;
  • seizure medicine--carbamazepine, divalproex sodium, lamotrigine, phenobarbital, phenytoin, valproate, valproic acid; or
  • steroid medicine--budesonide, dexamethasone, prednisone, fluticasone.
This list is not complete and many other drugs can interact with Kaletra. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

What should I watch for while taking this medicine?

Taking this medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What side effects may I notice from this medicine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Kaletra and call your doctor at once if you have:
  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting;
  • itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • high blood sugar (increased thirst, increased urination);
  • penis erection that is painful or lasts 4 hours or longer (if you take Kaletra with erectile dysfunction medication);
  • muscle weakness, tired feeling, joint or muscle pain, feeling short of breath; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Kaletra may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with Kaletra. Tell your doctor if you have:
  • signs of a new infection--fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;
  • chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;
  • cold sores, sores on your genital or anal area;
  • rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;
  • trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or
  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.
Common side effects may include:
  • nausea, vomiting, diarrhea;
  • high cholesterol; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Where can I keep my medicine?

Store the tablets at room temperature, away from heat and moisture. Keep the pills in their original container with the cap tightly closed.
Coronavirus disease – All you need to know about it

Coronavirus infection is a severe respiratory disease, which can cause complications and can lead to death.
Coronavirus is a group of respiratory syncytial viruses with a special RNA structure. The viruses infest animals.
Today, coronavirus disease exists in three types, which are most dangerous for human beings, namely:
SARS-CoV virus, which caused outbreak of atypical pneumonia in 2002

MERS-CoV virus, which caused Middle East respiratory syndrome of coronavirus in 2015
SARS-CoV-2 virus, which caused outbreak of new type of atypical pneumonia in 2020

The peculiarity of this type of infection is that viruses containing RNA constantly mutate. These have a specific mechanism of getting into cells. This is why typical methods of protection against viruses are ineffective, when it comes to this type of disease.
The key feature of this virus is that the body reacts to it as to a healthy substance at the very beginning. This is why, it’s rather difficult to recognize symptoms of the disease. As a result, the immune system doesn’t fight against the infection and it infests body cells rapidly.
How does the infection get into your body
Coronavirus epidemic is characterized by a fast airborne transmission of its particles. The infection is transmitted from a sick to healthy person through small saliva drops or mucus released during sneezing, coughing or talking. Direct-contact transmission is also possible.
According to scientists, Coronavirus outbreak in China happened because of contact-type transmission. The first infected people were found on the Wuhan market, where the infection spread through the contact with infected animals. It is considered that the virus has mutated in animals’ body and became dangerous for people. Earlier, it was believed that this type of coronavirus is unlikely to affect a human body.

Scientists have discovered that the latest SARS-CoV-2 coronavirus was also found in patients’ feces. It means that virus transmission is possible even during an accidental contact of healthy individual with other people and animals’ excreta. Also, in accordance with medical information, the virus can get into human’s body through ocular mucosa. This fact leaves almost zero chances for modern medicine to prevent the disease spreading.
Coronavirus symptoms
It can take several weeks from the moment of contamination until the confirmed disease diagnosis is discovered. This can lead to multiple human health complications.
To avoid this, it is necessary to detect the disease symptoms at its early stage.
The severe disease symptoms can manifest on different levels, depending on:
human immune system and general state of health
age
time passed from the moment of contamination
type of coronavirus infection
Initially, the symptoms are very similar to influenza virus or ARVI symptoms:
High body temperature,
Fatigue,
Headache,
Muscle pain or painful joints,
Sense of discomfort,
Loss of appetite, possible nausea and vomiting
Symptoms can gradually become more severe:
Diarrhea
Coordination disorder
Impaired judgement
Fever
Fainting
You can’t identify contamination by yourself. This is why if you suspect being infected, you need to go through a complete examination. As soon as clinical speciments are taken in a patient, he has to stay under the std control or hospitalized to a medical center.
Complications
Coronavirus can be asymptomatic. It can cause a real danger to patient’s health and life. Asymptomatic disease course for a long time can provoke a severe decrease in immunity and infectious diseases.
The most severe complication that can happen is atypical pneumonia, which can lead to respiratory insufficiency.
Healthcare professionals in Chinese hospitals have confirmed that some lab-based infection cases are registered as asymptomatic ones. Despite the fast developing pneumonia, patients felt fine and didn’t have any sense of discomfort. Only timely clinical research can show the necessity of hospitalization.
For whom Coronavirus is the most dangerous?

Chinese National health center has confirmed that the most vulnerable population is:
Elder people 60+.
Children younger than 16 years of age.
Doctor or assistant who cures coronavirus.

The highest number of deaths was registered in these groups of people.
The group of higher risk for contamination also contains people with chronic diseases, such as:
Bronchial asthma, chronic bronchitis
Congenital heart malformations, CAD, cardiac insufficiency
Pregnant women

In many cases, the treatment becomes complicated because not all pharmaceutical products can be used in elderly people, children or pregnant women. This is why scientists are currently looking for a universal pharma technology, which will help to develop a product that can be used in all population groups.
Coronavirus treatment

A new type of coronavirus SARS-CoV-2, which led to national quarantine in China, still doesn’t have a confirmed and effective treatment plan. All treatment methods are aimed at fighting the disease symptoms. At the same time, treating the secondary infection (pneumonia) requires antibacterial therapy, which, however, decreases the immunity level.
All patients with suspected coronavirus are quarantined in a medical center, the so-called diseases home. There, they get recovery assistance and control of health response to therapy methods used.
If hospitalization is impossible for any reason, and no evident signs of disease manifest, the patient is recommended home care.
If you notice having shortness of breath, spitting blood, increased expectoration, mental health changes or the GIT disfunction signs, health organization recommends immediate hospitalization for such patients and quarantine conditions for every person, who entered in contact with the patient.
Experimental treatment. HIV treating medicines for Coronavirus treatment
China and Japan are testing non-standard health medication to treat coronavirus. They hope to find a way to stop progression and mutation of viruses.
They have already started the clinical trials of HIV medicines for disease control and decrease in the spread of the virus. According to the data received from the Thailand ministry of health, the combination of medications used to treat HIV and influenza can stop the active virus replication phase.
Although the clinical studies are not finished yet, the sales of generics in China have already increased. Moreover, the demand for gilead HIV medicines in the country also increased.
Medicines for HIV treatment are intended to support the immune system and to provide infection control, as well.
Healthcare providers hope that drug development for coronavirus treatment will start in the nearest future. In the meantime, doctors try to prevent the spread of virus with the help of HIV services.
General Prevention Measures
Scientists from the national medical center in China have already confirmed that they have created the vaccine against coronavirus. However, they are not absolutely sure about its effectiveness. It will take not less than 1-1,5 years to study the clinical profile of global drug against coronavirus.
In the meantime, the only way to avoid contamination is to follow the basic preventive measures:
Remember about hygiene and wash your hands more often, after which you should also wash your face. Use antiseptics for infection prevention. Avoid any contacts with people, in whom you notice symptoms of virus. The highest risk of getting healthcare infection is in health clinic. Therefore, you should try to avoid visiting places, where you can meet many sick people. Keep a healthy lifestyle. You need to have a good sleep and observe a healthy diet. Drink more water. Aerate regularly the rooms, in which you spend time with other people. Wear a medical facemask if you go to a public place. Especially when you are at work or use public transport. Ask the management to comply with occupational health regulations. It’s very important when it comes to virus spread prevention. Avoid kissing and hugs.
It is not only China that works on vaccine development. The team of experts from cdc works on developing an effective treatment plan and prevent the virus transmission, as there is a high risk of the infection spread to the fourth world countries, where it will be extremely complicated to stop it.
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